You don't say how far they're travelling. If it's a long way, and if the time period is "now," then anything other than car, bus, or airplane is going to need some explanation. Only folks on the East Coast are going to be taking a train between cities/states. That is, if the pair is going from Chicago to New Orleans, I can't see them hopping the Amtrak unless there's some special reason; the cost and travel time don't make sense in comparison to air travel. If the pair is lower class, busses make perfect sense, but, like airplanes, they can be a bit cramped for a stage presentation.
You say
QUOTE
The type of transportation isn't particularly important to me
but it seems to me that in any realistic portrayal of travel, the mode is going to provide interesting dramatic opportunities unique to the mode. Security checkpoints in the airport, rest areas and gas stops for the car--not to mention driving habits, long exposure to travelling companions on the bus, etc.