The Coen brothers have tapped a pair of relative unknowns to star in their next pic, "A Serious Man."

Michael Stuhlbarg, a Tony-nominated actor with little experience in front of the cameras, and Richard Kind, a character actor best known for his role on ABC's "Spin City," will star as brothers in the period black comedy.

Set in 1967, story centers on Larry Gopnik (Stuhlbarg), a Midwestern professor whose life begins to unravel when his wife sets out to leave him and his socially inept brother (Kind) won't move out of the house.

NEW YORK, September 8th, 2008 – Production begins today on location in Minnesota on A Serious Man, for Focus Features and Working Title Films. Joel and Ethan Coen, Academy Award winners for No Country for Old Men and Fargo, are writing, producing, and directing the film. Working Title co-chairs Tim Bevan and Eric Fellner are executive-producing the film with Robert Graf, who has worked on the Coens’ last six features in various producing capacities.

The director of photography on A Serious Man is seven-time Academy Award nominee Roger Deakins, who is marking his tenth feature collaboration with the Coens. Mary Zophres is the film’s costume designer, marking her ninth feature collaboration with the Coens. Jess Gonchor is the production designer, marking his third feature collaboration with the Coens.

A Serious Man is the story of an ordinary man’s search for clarity in a universe where Jefferson Airplane is on the radio and F-Troop is on TV. It is 1967, and Larry Gopnik, a physics professor at a quiet midwestern university, has just been informed by his wife Judith that she is leaving him. She has fallen in love with one of his more pompous colleagues, Sy Ableman, who seems to her a more substantial person than the feckless Larry. Larry’s unemployable brother Arthur is sleeping on the couch, his son Danny is a discipline problem and a shirker at Hebrew school, and his daughter Sarah is filching money from his wallet in order to save up for a nose job. While his wife and Sy Ableman blithely make new domestic arrangements, and his brother becomes more and more of a burden, an anonymous hostile letter-writer is trying to sabotage Larry’s chances for tenure at the university. Also, a graduate student seems to be trying to bribe him for a passing grade while at the same time threatening to sue him for defamation. Plus, the beautiful woman next door torments him by sunbathing nude. Struggling for equilibrium, Larry seeks advice from three different rabbis. Can anyone help him cope with his afflictions and become a righteous person – a mensch – a serious man?

Tony Award nominee Michael Stuhlbarg (whose films include The Grey Zone) stars as Larry; Fred Melamed (Suspect) plays Sy; Richard Kind (The Visitor) portrays Arthur; and Minnesota actors Aaron Wolf, Sari Wagner, and Jessica McManus are cast as Danny, Judith, and Sarah, respectively.